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. 2013 Oct 29;109(12):3092–3104. doi: 10.1038/bjc.2013.655

Figure 3.

Figure 3

Ectopic miR-200b/c expression inhibits the migration and distant metastasis capacities of TFK-1 cells. (A) Lentivirus-transfected TFK-1 cells were used to construct a liver metastasis model of cholangiocarcinoma cancer cells. Images of the MRI scans are shown on the left line. Whole-liver serial sectioning for HE staining of the liver metastasis BALB/c-nude mice model. The micrometastases are shown on the right line. (B) Different tumour-initiating capacity of transfected TFK-1 cells. All the BALB/c-nude mice were killed at 6 weeks after injection. The weight data are shown in (C). The tumour diameters are shown in (D). All of the data were compared with those from the NC group. Abbreviations: BC=blank control group; NC=negative control group; 200b/c-U=200b/c-upregulated lentivirus group; 200b/c-D=200b/c downregulated lentivirus group.