Table 4. A second strategy tested the most frequent prognostic parameters for metastatic renal cancer, testing initial TS with osseous lesions and the MSKCC score.

Final multivariate cox proportional hazards models OS with 6-months landmark
Characteristic	Value	P value of multivariate analyses	HR	95% confidence interval
Initial tumour remission	100–60% 59–30% 29–0% 0–20% gain; >20% gain	<0.001	1.640	1.26–2.12
Bone metastases	Pts. with vs without bone metastases	0.043	1.884	0.89–2.41
MSKCC score	Good vs intermediate vs poor	0.138	1.462	1.02–3.47

Abbreviations: HR=hazards ratio; MSKCC=Memorial Sloan-Kettering Cancer Center; OS=overall survival; TS=tumour shrinkage.