Table 3. Diagnostic value of 18F-FDG PET/CT for the identification of recurrence or second primary cancers after curative treatment.
| TP | FP | FN | TN | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|---|---|---|
|
At 3–6 months (n=133) | |||||||||
| Local recurrence | 17 | 4 | 0 | 112 | 100 (80–100) | 97 (91–99) | 97 (92–99) | 81 (58–94) | 100 (96–100) |
| Regional recurrence | 11 | 6 | 1 | 115 | 92 (61–99) | 95 (89–98) | 95 (89–97) | 65 (38–85) | 99 (95–99) |
| Distant metastasis | 6 | 1 | 0 | 126 | 100 (54–100) | 99 (95–99) | 99 (95–99) | 86 (42–99) | 100 (97–100) |
| Second cancer |
2 |
4 |
5 |
122 |
29 (3–70) |
97 (92–99) |
93 (87–96) |
33 (4–77) |
96 (91–98) |
|
At 12 months (n=119) | |||||||||
| Local recurrence | 15 | 5 | 3 | 96 | 83 (63–95) | 95 (91–97) | 93 (87–97) | 75 (56–86) | 97 (93–99) |
| Regional recurrence | 8 | 5 | 0 | 106 | 100 (63–100) | 95 (89–98) | 96 (90–98) | 62 (31–86) | 100 (96–100) |
| Distant metastasis | 11 | 0 | 2 | 106 | 85 (54–98) | 100 (96–100) | 98 (94–99) | 100 (71–100) | 98 (93–99) |
| Second cancer | 4 | 5 | 1 | 109 | 80 (28–99) | 96 (90–98) | 95 (89–98) | 44 (13–78) | 99 (95–99) |
Abbreviations: CT=computed tomography; 18F-FDG=fluorine 18-fluorodeoxyglucose; FN=false negative; FP=false positive; NPV=negative predictive value; PET=positron emission tomography; PPV=positive predictive value; TN=true negative; TP=true positive.
Data in parentheses indicate the 95% confidence intervals.