Figure 2.

Co-treatment with persin and 4-OHT reverses 4-OHT resistance. (A) TAM-R and MCF 5-23 cells were treated with a non-apoptotic concentration of persin (1 μg ml⁻¹) or 4-OHT (7.5 μM) alone or in combination for 24 h, then attached and floating populations were analysed for M30-FITC positivity by flow cytometry. Overlays of representative histograms showing the M30-FITC-positive (apoptotic) fraction. (B) Bars, mean of M30-positive fractions from at least three independent experiments±s.e. **P<0.01, ***P<0.001, for combination treatment vs single treatment.