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. 2013 Dec 12;3:300. doi: 10.3389/fonc.2013.00300

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Copyright © 2013 Urayama, Thompson, Taylor, Trachtenberg and Chokkalingam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic map (not to scale) of the 7.6 Mb extended human MHC (xMHC) on the short (p) arm of human chromosome 6. The HLA class I gene cluster includes the three expressed classical class I genes, HLA-A, HLA-B, and HLA-C, and is located telomeric of the class III region. The HLA class II gene cluster is located centromeric of the HLA class III region. Of the over 250 known expressed loci of the xMHC, the relative locations of only those that have appeared in previous studies of childhood ALL are indicated.