Table 5.
Sepsis patients admitted to ICU through emergency department (ED): baseline patient characteristics in total cohort and in female vs. male patients.
| Variable | Septic ED cohort*, n = 43 | Female, n = 17 (40%) | Male, n = 26 (60%) | p-Value |
|---|---|---|---|---|
| AGE | ||||
| Age, median (range) | 64 (23–89) | 61 (26–76) | 71 (23–89) | 0.013 |
| MORTALITY, n (%) | ||||
| 28-day mortality | 8 (19) | 4 (24) | 4 (15) | 0.692 |
| 1-year mortality | 13 (30) | 5 (29) | 8 (31) | 1.0 |
| SEVERITY OF DISEASE, MEAN ± SD | ||||
| SOFA 0 h | 10 ± 3.3 | 9.9 ± 3.8 | 10 ± 3.1 | 0.970 |
| APACHE II | 24.1 ± 8.5 | 22.3 ± 8.9 | 25 ± 8.2 | 0.249 |
| UNDERLYING CONDITIONS, n (%) | ||||
| Previously healthy, n (%) | 11 (26) | 3 (18) | 8 (31) | 0.480 |
| Diabetes | 7 (16) | 2 (12) | 5 (19) | 0.685 |
| Smoking | 1 (2) | 0 (0) | 1 (4) | 1.0 |
| Alcohol abuse | 7 (16) | 2 (12) | 1 (4) | 0.685 |
| History of cancer | 10 (23) | 5 (29) | 5 (19) | 0.481 |
| Immunosuppressiona | 10 (23) | 5 (29) | 5 (19) | 0.481 |
| Hypertension | 14 (33) | 5 (29) | 9 (35) | 1.0 |
| Coronary artery disease | 6 (14) | 4 (24) | 2 (8) | 0.193 |
| Chronic heart failure | 3 (7) | 1 (6) | 2 (8) | 1.0 |
| CLINICAL MANIFESTATION, n (%) | ||||
| Pneumonia | 17 (40) | 7 (41) | 10 (38) | 1.0 |
| Urinary tract infection | 11 (26) | 6 (35) | 5 (19) | 0.296 |
| Intra-abdominal infection | 4 (9) | 0 (0) | 4 (15) | 0.140 |
| Skin/soft tissue infection | 6 (14) | 2 (12) | 4 (15) | 1.0 |
| Neutropenia | 1 (2) | 1 (6) | 0 (0) | 0.395 |
| Bacterial meningitis | 1 (2) | 1 (6) | 0 (0) | 0.395 |
| Undefined origin | 3 (7) | 0 (0) | 3 (12) | 0.266 |
| Time to see a physician, median (IQR) (min) | 20 (5–35) | 32 (8–39) | 12 (4–35) | 0.219 |
| Time to adequate antibiotics from triage, median (IQR) (min) | 86 (52–165) | 144 (70–185) | 67 (36–135) | 0.047 |
| CYTOKINES, MEDIAN (IQR) | ||||
| IL-6 (pg/mL) | 560 (106–3710) | 1902 (120–6925) | 477 (89–1373) | 0.2097 |
| IL-8 (pg/mL) | 79 (31–1708) | 200 (60–2362) | 43 (23–890) | 0.0729 |
| IL-10 (pg/mL) | 23 (9–67) | 32 (9–248) | 18 (9–53) | 0.2912 |
*Septic cohort of 43 patients with 34 patients with septic shock and 9 patients with severe sepsis coming to the ICU through the ED.
a According to APACHE II criteria.