Table 4.
Studies involving clinical and physiological effects of acute vaping.
| Authors (Reference) | Study design | Subjects | Study location | Key finding |
|---|---|---|---|---|
| STUDIES REPORTING POSITIVE OR NEUTRAL IMPACT OF E-CIGARETTES AND VAPING ON HEALTH | ||||
| Caponnetto et al. (113) | Three case reports | A 47-year old male A 38-year old female A 65-year old male | University of Catania, Catania, Italy | Participants successfully switched from conventional cigarettes to e-cigarettes and then quit e-cigarettes. Smoking cessation confirmed by exhaled carbon monoxide |
| Bahl et al. (119) | In vitro cultures | Human embryonic stem cells, and pulmonary fibroblasts | University of California, Riverside, California | Nicotine in e-cigarette refill fluids had no effect on the cytotoxicity of human embryonic stem cells |
| Flouris et al. (121) | Repeated-measures controlled study | Thirty human smokers (8 male) cycled through a control session, active smoking session, and active vaping session Fifteen never smokers (8 male) cycled through a control session, passive smoking session and passive vaping session | FAME Laboratory, Institute of Human Performance and Rehabilitation, Center for Research and Technology, Trikala, Greece | Acute smoking, but not acute vaping, induced increases in white blood cell count, lymphocyte count and granulocyte count |
| University of Thessaly, Trikala, and Larissa, Greece | ||||
| Palamas Health Center, Kardista, Greece | ||||
| University of Botswana, Botswana | ||||
| University of Crete, Crete, Greece | ||||
| University of Wolverhampton, United Kingdom | ||||
| Farsalinos and Romagna (123) | Case report | A 28-year old male with chronic iodiopathic neutrophilia | Onasis Cardiac Surgery Center, Kallithea, Greece and Abich ABICH S.r.l. Toxicological Laboratory, Verbania, Italy | Smoking cessation and e-cigarette use reversed symptoms of chronic iodiopathic neutrophilia. Smoking cessation was confirmed by exhaled carbon monoxide |
| Flouris et al. (79) | Repeated-measures controlled study | Thirty human smokers (8 male) cycled through a control session, active smoking session and active vaping session. Fifteen never smokers (8 male) cycled through a control session, passive smoking session, and passive vaping session | FAME Laboratory, Institute of Human Performance and Rehabilitation, Center for Research and Technology, Trikala, Greece | Vaping produced smaller changes in pulmonary function but similar nicotinergic impact compared to smoking |
| Romagna et al. (120) | In vitro cultures | Murine Fibroblasts | ABICH S.R.L. Toxicological Laboratory, Verbania, Italy | Extract of e-cigarette mist is less cytotoxic than extract of cigarette smoke to murine fibroblasts |
| STUDIES REPORTING NEGATIVE IMPACT OF E-CIGARETTES AND VAPING ON HEALTH | ||||
| Bahl et al. (119) | In vitro cultures | Human embryonic stem cells, and pulmonary fibroblasts | University of California, Riverside, California | The number and concentration of chemicals (other than nicotine) used to flavor e-cigarette refill fluids increased cytotoxicity |
| McCauly et al. (99) | Case report | A 42-year woman with exogenous lipoid pneumonia | Legacy Good Samaritan Medical Center, Portland, Oregon | Termination of e-cigarette use cleared the exogenous lipoid pneumonia |
| Vardavas et al. (100) | Laboratory-based intervention study | Active vaping (experimental) for 5 min in smokers (14 men) versus passive vaping (control) for 5 min in 10 smokers randomly selected from the experimental group | Participants from a community in Athens, Greece | Five minutes acute vaping-induced a decrease in exhaled nitric oxide, and an increase in airway resistance and impedance in experienced smokers |