Table 4.

Potential adverse effects of marijuana^a (see text).

Addiction (physiologic)

Withdrawal syndrome

Dependence (psychological) and with heavy use, tolerance

Variety of negative psychological reactions: anxiety, hallucinations, violent behavior, depression, fear

Overt precipitation of psychosis or depression

Insomnia (can be chronic and improved with trazodone)

Memory spans that are impaired

Blunted reflexes

Flu-like reaction (after stopping this drug after 24–60 h, lasting up to 2 weeks)

Confusion and cognition impairment

Alteration of time perception

Amotivational syndrome (lose interest in school or work success)

Physiologic responses can include cough, bronchospasm, bronchitis

Amenorrhea

Immunologic dysfunction

^aUsed with permission from Ref. (14).