Table 4.
Amino acid changes in the pre-S region.
| Subject | B-cell epitope | T-cell epitope | Region outside the B- and T-cell epitopes | |||||
|---|---|---|---|---|---|---|---|---|
| Pre-S1 | Pre-S2 | Pre-S1 | Pre-S2 | |||||
| aa 12–32, aa 27–35, aa 41–53, aa 72–78 |
aa 19–26, aa 32–47, aa 37–45, aa 94–105, aa 106–117 |
aa 1–6, aa 3–15, aa 13–24 |
aa 38–48 | aa 29–48 | aa 12–21, aa 21–30, aa 94–105, aa 106–117 |
aa 21–30, aa 29~48 |
||
| Y1 | N48H | Wild-type | G16R | Wild type | N48H | Wild-type | Wild-type | V60A, L85F |
| Y2 | N48H | Wild-type | G16R | Wild type | N48H | Wild-type | Wild-type | M12T, N15S, N20S, T68I, Q82S, L84I, V172A |
| Y3 | N48H | Wild-type | G16R | Wild type | N48H | Wild-type | Wild-type | T68I, Q82S, L84I, V172A |
| Y4 | N48H | Wild-type | G16R | Wild type | N48H | Wild-type | Wild-type | T68I, Q82S, L84I, V172A |
| Y5 | G27D, Q51H, S73G | Wild-type | S6T | Wild type | Wild-type | Wild-type | Wild-type | Q10K, A54E, H56N, V60A, S62A, A90V, L173P |