Table 2.
Topological properties of the 2-HN for SHU formula and its three subnetworks.
| Property | CSN | PSN | GSN | 2-HN | |
|---|---|---|---|---|---|
| Node | Compounds | 171 | 50 | 0 | 171 |
| Proteins | 0 | 238 | 238 | 238 | |
| Edge | CCIs | 481 | 0 | 0 | 481 |
| CPIs | 0 | 1101 | 0 | 1101 | |
| PPIs | 0 | 0 | 718 | 718 | |
| Connected components | 34 | 1 | 57 | 1 | |
| Isolated nodes | 17 | 0 | 55 | 0 | |
| Clustering coefficient | 0.662 | 0.0 | 0.198 | 0.414 | |
| Network density | 0.033 | 0.027 | 0.025 | 0.028 | |
| Network heterogeneity | 0.664 | 2.531 | 1.287 | 1.588 | |
*CCI is short for compound-compound interaction, CPI is compound-protein interaction, and PPI is protein-protein interaction. CSN represents the chemical subnetwork of the 2-HN for SHU formula, PSN the pharmacological subnetwork, and GSN the genomic subnetwork.
*All the topological properties were calculated using Cytoscape 2.8 [32].