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. Author manuscript; available in PMC: 2014 Aug 23.
Published in final edited form as: J Mol Biol. 2013 May 23;425(16):10.1016/j.jmb.2013.05.013. doi: 10.1016/j.jmb.2013.05.013

Fig. 1.

Fig. 1

Regiospecific phosphorylation model controlling SRSF1 nuclear–cytoplasmic localization. Cytoplasmic SRPK1 phosphorylates RS1 in the RS domain allowing nuclear translocation of SRSF1. Nuclear CLK1 then phosphorylates the serines in RS2.