. Author manuscript; available in PMC: 2014 May 25.

Published in final edited form as: Virology. 2013 Mar 21;440(1):10.1016/j.virol.2013.02.008. doi: 10.1016/j.virol.2013.02.008

Table 1.

Integration site distribution for Nup153 and Nup98 depleted cells.

Genomic features	Jurkat control	Jurkat Nup98KD	Jurkat Nup153KD	Random
Genomic features	n=798	n=1518	n=893	n=40,000
% Intragenic integrations (±50 kb)	77.0	72.0	69.0	38.0
% Intergenic integrations (±50 kb)	21.0	23.0	28.0	59.0
% TSS-proximal integrations (±50 kb)	1.7	4.5	3.0	3.0
% Integrations on CpG islands (±50 kb)	67.5	69.4	63.7	38.7
% Integrations in DNaseI hypersensitive sites (±50 kb)	97.9	97.1	95.7	83.1
Gene density/integration (±50 kb)	2.0	2.2	1.9	0.9
Average genes in 1 Mb	46.0	47.0	44.0	30.0

The table indicates the percentage of HIV integrations occurring in intragenic, intergenic, transcriptional start site (TSS)-proximal regions, and in close proximity to CpG islands and in DNaseI hypersensitive sites. Computer-generated random control sequences were obtained from Cattoglio et al.(2010).