Table 2. The frequency of Grade 3 or 4 treatment related toxicities in 51 patients with metastatic colorectal cancer treated with celecoxib, capecitabine, and irinotecan.
| Type of toxicity | Grade 3 | Grade 4 | ||
|---|---|---|---|---|
|
|
|
|||
| Number | Percentage | Number | Percentage | |
| Neutropenia | 5 | 10 | 0 | 0 |
| Diarrhea | 12 | 24 | 5 | 10 |
| Fatigue | 3 | 6 | 1 | 2 |
| Nausea | 3 | 6 | 1 | 2 |
| Vomiting | 1 | 2 | 2 | 4 |
| Infection | 1 | 2 | 0 | 0 |
| Stomatitis | 1 | 2 | 0 | 0 |
| Hand foot syndrome | 7 | 14 | 0 | 0 |
The data are expressed as the worst toxicity per patient. Toxicity was assessed using the NCI-CTC Version 2.0 scale for toxicity grading [25]