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. 2013 Dec 15;126(24):5541–5552. doi: 10.1242/jcs.115972

Fig. 7.

Fig. 7.

The phosphorylation of eNOS on S1176 is crucial for vascular permeability and inflammation in vivo. (A) VEGF-induced dermal vascular permeability was reduced in S1176A eNOS (loss of function) mice compared to WT and S1176D eNOS (gain of function) mice. The data are plotted as the VEGF:PBS ratio of individual mice. *P<0.05; n = 5 mice per group. (B) Representative images of Evan's blue leakage upon PBS or VEGF injection of the mice described in A. (C) Histamine-induced dermal vascular permeability was reduced in S1176A eNOS mice compared to WT and S1176D eNOS mice. (D,E) S1176A eNOS mice displayed a significant reduction of carrageenan-induced (D) exudate formation and (E) neutrophil recruitment into the air pouches 4 hours post-instillation compared to WT and S1176D eNOS mice (n = 5, per group). The data shown represent the mean±s.e.m. *P<0.05, **P<0.01 compared to WT group.