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. 2013 Dec 15;126(24):5635–5644. doi: 10.1242/jcs.132795

Fig. 2.

Fig. 2.

Altered blood glucose regulation in K8−/− mice. (A) Blood glucose levels are shown after overnight fasting in K8−/− mice (black bar) and K8+/+ mice (white bar). Bars represent means±s.e.m., n = 14 K8+/+ and 11 K8−/− mice. (B) Glucose tolerance is shown for K8−/− (grey broken line) and K8+/+ (black line) mice as mean±s.e.m. blood glucose values as a function of time after glucose administration. (C) Insulin tolerance for K8−/− (grey broken line) and K8+/+ (black line) mice is shown as mean±s.e.m. blood glucose values as a function of time after i.p. insulin administration. n = 10 K8+/+ and 8 K8−/− mice for B and C. (D) Basal serum insulin and glucose-stimulated serum insulin levels (GSIS) 10 minutes after i.p. glucose 2 g/kg of body weight in K8+/+ mice (white bar) and K8−/− (black bar) mice shown as mean±s.e.m. serum insulin levels, n = 9 mice/group for fasting insulin, and 3 K8+/+ and 4 K8−/− mice for glucose-stimulated insulin levels. *P<0.05, **P<0.01, ***P<0.001 compared with K8+/+ (A–C) or basal (D).