Fig. 5.

Delayed hyperglycaemia but increased exocrine injury in K8^−/− mice after low-dose STZ treatment. (A) Diabetes incidence is shown for K8^+/+ (black solid line) and K8^−/− (broken grey line) mice after five low-dose STZ i.p. injections during the first 5 days (arrows). n = 13 K8^+/+ and 11 K8^−/− mice. (B) Mean±s.e.m. blood glucose levels at the start of the experiments, and at 1 and 2 weeks after low-dose STZ injections in K8^+/+ (white bars) and K8^−/− (black bars) mice. n = 13 K8^+/+ and 11 K8^−/− mice. *P<0.05, **P<0.01 calculated with one-way ANOVA and Bonferroni's posthoc test. (C) Representative haematoxylin-eosin staining of the exocrine pancreatic damage 5 weeks after low-dose STZ treatment in K8^+/+ and K8^−/− mice. Extensive oedema can be seen in the K8^−/− pancreas. v, vacuoles, the black arrow indicates hyperplasia, the arrowhead shows atrophy and I, islet, which in this picture also contains some inflammatory cells. Scale bar: 200 µm.