Table 1. Damage scores for the exocrine pancreas in K8+/+ and K8−/− mice shows increased damage in K8−/− 5 weeks after low-dose STZ treatment.
The exocrine pancreas was given a score between 0 and 3 for acinar cell hyperplasia, vacuole formation, atrophy (loss of acinar cell structure), lipid infiltration, oedema and presence of inflammatory cells, where 0, no changes and 3, major changes compared to untreated mice. The numbers present the mean score ± s.d. (n = 3) for K8+/+ and K8−/− mice (10 random and blinded sections from each mouse were analysed and scored). The total scores retrieved for each mouse were used for the statistical analysis of the data. The difference between the exocrine damage in K8+/+ and K8−/− is significant (P<0.05), as calculated with Mann–Whitney's U-test.