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. 2013 Dec 15;126(24):5645–5656. doi: 10.1242/jcs.132985

Fig. 8.

Fig. 8.

Model of IR isoform switching along the axis of proliferating crypt stem and progenitors to post-mitotic differentiated lineages and in adenoma formation. Our results support a model where IR-A expression is enriched in IESCs and progenitors (crypt), whereas IR-B expression is enhanced in post-mitotic, differentiated lineages (villus). IEC differentiation involves increased expression of exon 11 splicing enhancer MBNL2 and decreased expression of CUGBP1, exon 11 splicing silencer. These changes parallel the increase in IR-B in post-mitotic, differentiated IECs. During tumor formation, we propose that MBNL2 levels decrease, promoting a parallel decrease in IR-B expression. CUGBP1, CUG triplet repeat RNA-binding protein 1; MBNL2, muscleblind-like 2.