Table 5. Interaction between genes related to growth factors.
| Gene 1 | Gene 2 | wt 1/variant 2 OR (95% CI)1 | variant 1/wt 2 OR (95% CI) | variant 1/variant 2 OR (95% CI) | p interaction |
|---|---|---|---|---|---|
| EGFR | |||||
| (rs6944906) | FGF1 (rs152528) | 0.76 (0.59,0.99) | 0.82 (0.71,0.95) | 0.785 (0.70,1.05) | 0.02 |
| FGF2 (rs1960669) | 0.83 (0.67,1.03) | 0.86 (0.77,0.96) | 1.05 (0.89,1.24) | <0.01 | |
| (rs1558544) | FGF2 (rs308395) | 0.85 (0.65,1.10) | 0.67 (0.50,0.89) | 0.83 (0.30,2.31) | <0.01 |
| FGF2 (rs167428) | 0.79 (0.63,0.98) | 0.66 (0.47,0.91) | 1.21 (0.62,2.38) | 0.01 | |
| FGF2 (rs11837725) | 0.84 (0.66,1.08) | 0.62 (0.46, 0.83) | 0.70 (0.19,2.49) | 0.02 | |
| FGF2 (rs308441) | 0.72 (0.56,0.93) | 0.70 (0.52,0.94) | 1.50 (0.61,3.71) | <0.01 | |
| (rs6593205) | FGF2 (rs1476214) | 1.05 (0.83,1.33) | 0.67 (0.54,0.83) | 1.27 (0.88,1.83) | 0.03 |
| FGF2 (rs3789138) | 0.93 (0.75,1.14) | 0.68 (0.53,0.87) | 1.11 (0.82,1.51) | 0.03 | |
| FGF2 (rs3804158) | 0.96 (0.78,1.18) | 0.66 (0.51,0.86) | 1.16 (0.87,1.57) | 0.02 | |
| (rs17151957) | EGF (rs4444903) | 0.90 (0.75,1.08) | 0.61 (0.43,0.86) | 0.97 (0.69,1.36) | 0.03 |
| (rs6970262) | FGF1 (rs4912876) | 0.86 (0.68,1.09) | 0.87 (0.69,1.10) | 1.60 (1.00,2.54) | 0.01 |
| (rs723527) | FGF2 (rs308441) | 0.69 (0.48,0.99) | 0.90 (0.76,1.07) | 1.12 (0.72,1.75) | 0.02 |
| (rs3752651) | FGF1 (rs34019) | 0.86 (0.76,0.97) | 0.96 (0.72,1.29) | 2.60 (1.30,5.17) | <0.01 |
| ERBB2 | |||||
| (rs1810132) | FGF1 (rs34016) | 0.79 (0.55,1.13) | 0.77 (0.64,0.93) | 1.70 (0.87,3.34) | 0.01 |
| (rs1136201) | EGFR (rs11770531) | 0.71 (0.44,1.15) | 1.04 (0.94,1.15) | 0.25 (0.10,0.62) | 0.04 |
| FGFR2 | |||||
| (rs2981582) | FGF2 (rs7700205) | 1.33 (1.14,1.55) | 0.80 (0.66,0.97) | 1.85 (1.44,2.38) | <0.01 |
| FGF2 (rs17408757) | 1.40 (1.21,1.62) | 0.87 (0.71,1.07) | 1.79 (1.36,2.34) | 0.03 | |
| FGF2 (rs1960669) | 1.36 (1.17,1.58) | 0.87 (0.70,1.09) | 1.97 (1.47,2.63) | 0.01 | |
| FGF2 (rs6534365) | 1.24 (1.03,1.50) | 1.03 (0.77,1.38) | 1.65 (1.12,2.43) | 0.03 | |
| EGFR (rs17586365) | 0.84 (0.44,1.61) | 1.40 (1.21,1.63) | 7.77 (2.24,26.93) | 0.03 | |
| (rs6954351) | 1.27 (0.61,2.62) | 1.63 (1.40,1.89) | 2.22 (0.85,5.78) | 0.02 | |
| PDGFB | |||||
| (rs9622978) | FGF1 (250092) | 0.95 (0.82,1.09) | 1.03 (0.91,1.17) | 0.59 (0.44,0.79) | <0.01 |
| FGF1 (rs4912868) | 0.70 (0.57,0.86) | 0.91 (0.78,1.07) | 1.16 (0.82,1.62) | <0.01 | |
| (rs2247128) | FGF1 (rs4912868) | 0.87 (0.66,1.13) | 0.88 (0.73,1.07) | 1.97 (1.07,3.63) | 0.04 |
| (rs6001512) | FGF2 (rs308435) | 1.01 (0.85,1.20) | 1.02 (0.91,1.14) | 1.47 (1.13,1.93) | 0.03 |
| NRG2 | |||||
| (rs265159) | EGFR (rs2280653) | 0.65 (0.45,0.92) | 1.03 (0.82,1.30) | 1.85 (0.71,4.81) | <0.01 |
| FGF1 (rs1609763) | 1.02 (0.83,1.25) | 1.08 (0.89,1.33) | 1.72 (1.01,2.95) | 0.04 | |
| (rs3863190) | EGFR (rs9642391) | 0.93 (0.78,1.11) | 0.83 (0.51,1.35) | 8.47 (1.91,37.54) | 0.02 |
| (rs2330951) | 1.00 (0.81,1.25) | 1.59 (1.03,2.46) | 0.68 (0.22,2.10) | 0.02 | |
| (rs2280653) | 0.95 (0.71,1.27) | 1.73 (1.14,2.62) | 0.44 (0.05,4.29) | 0.05 | |
| FGF1 (rs34019) | 0.95 (0.84,1.09) | 1.52 (1.05,2.21) | 0.49 (0.21,1.14) | <0.01 | |
| (rs265155) | EGFR (rs12671550) | 1.00 (0.87,1.16) | 1.73 (1.20,2.50) | 0.74 (0.36,1.51) | 0.02 |
| (rs2916092) | EGFR (rs11770531) | 0.23 (0.12,0.46) | 0.97 (0.82,1.14) | 0.98 (0.24,3.94) | <0.01 |
| (rs4912894) | PDGFB (rs4821877) | 1.32 (1.05,1.66) | 1.07 (0.81,1.41) | 0.92 (0.71,1.21) | 0.05 |
| (rs1800954) | EGFR (rs172718945) | 1.07 (0.97,1.18) | 1.03 (0.48,2.23) | 0.42 (0.24,0.73) | 0.04 |
| (rs17151957) | 0.96 (0.80,1.15) | 0.34 (0.18,0.66) | 1.33 (0.18,9.57) | 0.04 | |
| rs(1422187) | EGFR (rs4947979) | 1.60 (1.13,2.26) | 1.17 (0.89,1.54) | 0.67 (0.26,1.73) | 0.01 |
| (rs197197) | FGF2 (rs11938826) | 0.65 (0.44,0.96) | 0.86 (0.72,1.01) | 0.77 (0.52,1.16) | 0.01 |
| (rs11746363) | EGFR (rs917880) | 0.83 (0.70,0.98) | 0.68 (0.45,1.02) | 0.91 (0.53,1.57) | 0.05 |
| (rs13173983) | EGFR (rs2280653) | 0.79 (0.56,1.11) | 0.72 (0.56.0.93) | 0.50 (0.13,1.93) | 0.02 |
| FGF1 (rs152528) | 1.08 (0.88,1.31) | 0.97 (0.69,1.35) | 0.55 (0.33,0.92) | 0.05 | |
| (rs6580353) | EGFR (rs11770531) | 0.81 (0.46,1.42) | 1.03 (0.86,1.22) | 0.10 (0.01,0.76) | 0.02 |
| FGF2 (rs11938826) | 0.72 (0.53,0.97) | 0.90 (0.72,1.12) | 1.61 (0.88,2.96) | 0.03 | |
| (rs2436389) | EGFR (rs11487218) | 1.14 (0.88,1.48) | 1.25 (1.10,1.42) | 0.97 (0.77,1.23) | 0.01 |
| (rs10225877) | 1.42 (0.96,2.11) | 1.26 (1.13,1.41) | 0.96 (0.6,1.41) | <0.01 | |
| (rs6944906) | 0.85 (0.72,0.97) | 0.98 (0.84,1.15) | 1.02 (0.89,1.17) | 0.04 | |
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, study, BMI during the referent year, parity and genetic admixture; table includes only statistically significant interactions