Table 3.
Predictors of OS in univariate and multivariate Cox regression analysis
| Characteristic | Univariate analysis
|
Multivariate analysis
|
||||||
|---|---|---|---|---|---|---|---|---|
| p | HR | 95 % CI
|
p | HR | 95 % CI
|
|||
| Lower | Upper | Lower | Upper | |||||
| Age, years (<50 vs. ≥50) | 0.604 | 0.722 | 0.211 | 2.468 | – | – | – | – |
| Menopausal status (pre- vs. post-) | 0.955 | 0.966 | 0.289 | 3.224 | – | – | – | – |
| Pathologic stage (0 vs. I) | 0.974 | 0.000 | 0.000 | – | – | – | – | – |
| Pathologic stage (0 vs. II) | 0.105 | 0.161 | 0.018 | 1.462 | – | – | – | – |
| Pathologic stage (0 vs. III) | 0.088 | 0.320 | 0.086 | 1.186 | – | – | – | – |
| Tumor size | 0.620 | 1.051 | 0.862 | 1.282 | – | – | – | – |
| Lymph node metastasis (0–3 vs. ≥4) | 0.125 | 2.552 | 0.772 | 8.434 | – | – | – | – |
| Tumor grade (1 and 2 vs. 3) | 0.803 | 0.844 | 0.224 | 3.189 | – | – | – | – |
| Lymphatic invasion (negative vs. positive) | 0.035 | 3.777 | 1.100 | 12.970 | 0.685 | 0.399 | 0.005 | 34.039 |
| Vascular invasion (negative vs. positive) | 0.033 | 3.829 | 1.115 | 13.146 | 0.919 | 0.793 | 0.009 | 70.007 |
| Expression of Ki67 | 0.874 | 0.994 | 0.924 | 1.070 | – | – | – | – |
| Postoperative local radiation therapy (received vs. not received) | 0.972 | 1.024 | 0.272 | 3.862 | – | – | – | – |
| Hormonal therapy (received vs. not received) | 0.033 | 0.275 | 0.084 | 0.903 | 0.086 | 2.940 | 0.858 | 10.072 |
OS overall survival, CI confidence interval, HR hazard ratio