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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Eur J Pharm Biopharm. 2013 Feb 16;84(2):10.1016/j.ejpb.2013.01.019. doi: 10.1016/j.ejpb.2013.01.019

Figure 1.

Figure 1

Maximum tolerated doses (MTD) (in mg/kg) of dendrimers determined by a dose escalation study in CD-1 mice. The acute oral toxicity study revealed that most dendrimers were safe to administer orally except for G7-NH2 and G7-OH, which exhibited signs of toxicity at relatively low dosage.