Table 2.
Treatment group | No. of mice |
> 10% body weight loss |
Other signs of toxicity |
---|---|---|---|
G7 −NH2 | |||
| |||
50mg/kg | 5 | 1 | Hemobilia |
30mg/kg | 5 | 0 | No |
| |||
G7-OH | |||
| |||
100mg/kg | 5 | 0 | No |
300mg/kg | 5 | 1 | Splenomegaly |
200mg/kg | 5 | 0 | No |
| |||
G 6.5-COOH | |||
| |||
100mg/kg | 5 | 0 | No |
300mg/kg | 5 | 0 | No |
500 mg/kg | 5 | 0 | No |
| |||
G4 −NH2 | |||
| |||
50mg/kg | 5 | 0 | No |
100mg/kg | 5 | 0 | No |
300mg/kg | 5 | 0 | No |
| |||
G4-OH | |||
| |||
100mg/kg | 5 | 0 | No |
300 mg/kg | 5 | 0 | Elevated BUN level in 1 mice |
500 mg/kg | 5 | 0 | No |
| |||
G3.5-COOH | |||
| |||
100mg/kg | 5 | 0 | No |
300mg/kg | 5 | 0 | No |
BUN - Blood Urea Nitrogen