. Author manuscript; available in PMC: 2014 Jun 1.

Published in final edited form as: Eur J Pharm Biopharm. 2013 Feb 16;84(2):10.1016/j.ejpb.2013.01.019. doi: 10.1016/j.ejpb.2013.01.019

Table 2.

Acute toxicity doses administered orally to CD-1 mice

Treatment group	No. of mice	> 10% body weight loss	Other signs of toxicity
G7 −NH₂

50mg/kg	5	1	Hemobilia
30mg/kg	5	0	No

G7-OH

100mg/kg	5	0	No
300mg/kg	5	1	Splenomegaly
200mg/kg	5	0	No

G 6.5-COOH

100mg/kg	5	0	No
300mg/kg	5	0	No
500 mg/kg	5	0	No

G4 −NH₂

50mg/kg	5	0	No
100mg/kg	5	0	No
300mg/kg	5	0	No

G4-OH

100mg/kg	5	0	No
300 mg/kg	5	0	Elevated BUN level in 1 mice
500 mg/kg	5	0	No

G3.5-COOH

100mg/kg	5	0	No
300mg/kg	5	0	No

BUN - Blood Urea Nitrogen