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. Author manuscript; available in PMC: 2013 Dec 12.
Published in final edited form as: J Neurophysiol. 2008 Feb 20;99(5):10.1152/jn.01192.2007. doi: 10.1152/jn.01192.2007

FIG. 7.

FIG. 7

Application of oxotremorine to a subset of synaptically isolated pacemakers suppressed faster eupneic-like burst activity and triggered large sigh-like bursting activity. A: as was seen at the network level, oxotremorine application (20 µM) also triggered sigh-like bursts and suppressed shorter eupneic-like bursting activity in some isolated pacemakers. Shorter eupneic bursts returned with continued application (boxed area). Bottom trace is expansion of area boxed in top trace. Note that sigh-like bursting activity resulted in a phase reset of the eupneic-like bursts. Ten minutes prior to adding oxotremorine, flufenamic acid (FFA, 500 µM) was added; FFA-insensitive pacemakers are typically cadmium insensitive [as previously shown (Peña et al. 2004)]. B: not all cadmium-insensitive pacemakers that intrinsically generated differential bursting patterns, following synaptic isolation (top traces), continued to generate bursting with subsequent oxotremorine application (bottom traces, n = 2).