Table 1. Clinical and tumour characteristics.
IDC, invasive ductal carcinoma; HG3, histological grade 3; N+, positive node.
| Author | Biomarkers | City, Country | Sample size (n) | Age (years) | IDC (%) | HG3 (%) | N+ (%) | ER+ (%) | PR+ (%) |
|---|---|---|---|---|---|---|---|---|---|
| Zhang et al. [30] | MMP13 | Tianjin, China | n=263 | Median: 50.3 | 100 | 29 | 51 | 62 | 62 |
| Nakopoulou et al.[36] | TIMP2 | Athens, Greece | n=136 | Mean: 57.09 (25–87) | 79 | 25 | 58 | 54 | 50 |
| Ioachim et al.[35] | THBS1 | Ioannina, Greece | n=124 | - | 61 | 39 | 66 | 68 | 60 |
| Jung et al. [34] | LGALS1 | Jinju, Korea | n=105 | Mean: 39.3±9.8 | 41 | - | 40 | 87 | 87 |
| Schoppmann et al. [32] | PDPN | Vienna, Austrian | n=367 | Mean: 61±13 | 87 | 40 | 43 | 79 | - |
| Pula et al.[28] | PDPN | Wroclaw, Poland | n=117 | Mean: 56.6±11.3 (30–83) | 100 | 35 | 49 | 76 | 65 |
| Dublin et al.[31] | PLAU, PLAUR, PAI1 | U.K. | n=142 | Median: 56 (28–86) | 62 | 34 | 63 | - | - |
| Witkiewicz et al. [37] | CAV1 | Michigan, U.S.A. | n=154 | Median: 59.5 (28–96) | - | 46 | 52 | 70 | 56 |
| Present Series | MMP13, PDPN, CAV1 | Pouso Alegre, Brazil | n=65 | Mean: 57.7±13.9 (23–84) | 100 | 40 | 54 | 59 | 50 |