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. Author manuscript; available in PMC: 2014 Feb 23.
Published in final edited form as: Science. 2013 Aug 8;341(6148):10.1126/science.1240933. doi: 10.1126/science.1240933

Figure 4. Murine leukemia virus and simian immunodeficiency virus activate innate immune responses through cGAS.

Figure 4

(A and B) L929 cGAS KO clone#18 and the parental L929 cells stably expressing shRNA against TREX1 or luciferase (control) were infected with MLV-GFP (MOI=2) for 20 h, followed by measurement of IFNβ (A) and CXCL10 (B) RNA by q-RT-PCR. (C and D) Similar to (A and B), except that cells were infected with SIV-GFP (MOI=1.5) for 20 h.