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The L–R pattering is caused at the node by an early breaking of bilateral symmetry. The nodal gene is essential in this function and the midline acts as a physical and molecular barrier to determine correct side-specific gene expression. The leftward Nodal flow (arrow) transport to the left wall of the node the nodal vesicular parcels. At this level Nodal interplays with other signalings including Notch, LeftyA, Cryptic, Pitx2, etc. (Modified from Zhu et al 2006; 14:14–25)
