Fig. 2.

(A), (B) Adenocarcinoma in situ of the cervix. (A) Adenocarcinoma in situ of the endocervix is generally characterized at medium magnification by the preservation of normal glandular architecture, with an abrupt transition between normal and cytologically atypical cells. (B) At higher magnification, the features are evident, including nuclear enlargement, coarse chromatin, and stratification of nuclei. (C) Left inguinal lymph node with metastatic poorly differentiated adenocarcinoma of the cervix. (D) Positive high-risk human papilloma virus (HPV) DNA in situ hybridization.