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Silencing of NFAT1 in cultured chondrocyte cells decreased the levels of TNF-α and MMPs stimulated by IL-1β.
| Group | TNF-α | MMP-1 | MMP-3 | MMP-9 |
|---|---|---|---|---|
| Scrambled control | 0.93±0.10 | 0.95±0.06 | 0.92±0.07 | 1.04±0.12 |
| NFAT1-siRNA | 0.63±0.05a | 0.71±0.07a | 0.66±0.03a | 0.58±0.04b |
P<0.05,
P<0.01 vs. the control.
NFAT1, nuclear factor of activated T cells 1; TNF-α, tumor necrosis factor-α; MMP, matrix metalloproteinase; IL-1β, interleukin-1β.
