Table 2. The various functions assigned to nsSNPs in each set.

Set	Site	Ligand	Site/ligand overlap	Metal	Catalytic	Overall (non-redundant)
3D	1,414	1,432	1,220	334	17	1,648 (15.5%)
Monomer	281	273	245	83	4	312 (21.4%)
OMIM	163	184	147	17	17	209 (2.1%)
Humsavar	305	285	252	58	41	355 (51.2%)
Models	1,538	1,443	1,304	376	36	1,676 (12.9%)

‘Site’ refers to residue specific annotations made by depositors of PDB structures, ‘Ligand’ refers to residues involved in binding a ligand, ‘Metal’ refers to residues coordinating with metals and ‘Catalytic’ to residues involved in the catalytic activity of the protein. The % of non-redundant assigned residues that are ‘functional’ is also shown.