Table 2.
List of Crystal Structures for Mammalian KMT and KDM Enzymes
| Enzyme | First Catalytic Domain | Crystal with Substrate | |
|---|---|---|---|
| KMTs | KMT1B | 2R3A | – |
| KMT1C | 2O8J | – | |
| KMT1D | 2IGQ | 3SW9 DNMT3AK44me0 and SFG | |
| 3SWC DNMT3AK44me2 and SAH | |||
| 3HNA H3K9me1 and SAH | |||
| 2RFI H3K9me2 and SAH | |||
| KMT2A | 2W5Y | 2W5Z histone peptide and SAH | |
| KMT2H | 3OPE | – | |
| KMT3A | 3H6L | – | |
| KMT3B | 3OOI | – | |
| KMT3C | 3QWV | 3S7D p53me and SAH | |
| 3S7F p53 and SAM | |||
| 3TG5 p53 and SAH | |||
| KMT3E | 3MEK | – | |
| KMT4 | 1NW3 | – | |
| KMT5A | – | 1ZKK H4 peptide (16–24) and SAH | |
| 3F9Y Y334F H4K20me1 and SAH | |||
| 3F9X Y334F H4K20me2 and SAH | |||
| KMT5B | 3S8P | – | |
| KMT5C | 3RQ4 | – | |
| KMT7 | 1MUF | 3OS5 Dnmt1K142me1 and SAH | |
| 2F69 TAF10 and SAH | |||
| 3M55 TAF10K189me1 and SAH | |||
| 3M56 TAF10K189me2 and SAH | |||
| 3M5A TAF10K189me3 and SAH | |||
| 1XQH p53 and SAH | |||
| KMT8A | 2JV0 | – | |
| KDMs | JMJD6 | 3K2O | – |
| KDM1A | 2H94 | 2V1D H3, COREST and FAD | |
| 2UXN H3, COREST and FDA | |||
| KDM1B | 3KV5 | – | |
| KDM2A | 2YU2 | – | |
| KDM4A | 2GP3 | 2OT7 H3K9me1 OGA | |
| 2OX0 H3K9me2 OGA | |||
| 2OQ6 H3K9me3 OGA | |||
| 2Q8C H3K9me3 AKG | |||
| 2PXJ H3K36me1 OGA | |||
| 2Q8D H3K36me2 SIN | |||
| 2OS2 H3K36me3 OGA | |||
| 2YPB H3K36me3 2HG | |||
| 2YBS H3K36me3 S2G | |||
| 3U4S H3 O8P | |||
| 2P5B H3k36me3 OGA | |||
| KDM4C | 2XML | – | |
| KDM4D | 3DXU | – | |
| KDM6A | 3AVS | 3AVR H3K27me3 and OGA | |
| KDM6B | 2XXZ | – | |
| KDM7B | 2WWU | 3KV4 H3 and OGA | |
| KDM8 | 3UYJ | – |
OGA, N-oxalylglycine; SIN, succinic acid; AKG, 2-oxoglutaric acid; SAH, S-adenosyl-L-homocysteine; SAM, S-adenosylmethionine; SFG, sine-fungin; FAD, flavin-adenine; FDA, dihydroflavine-adenine dinucleotide.