Table IV.
Comparison of the genotype frequencies of the SOD 2 polymorphisms between OSCC patients and controls.
| SNP | Model/Allele | Genotype | Case (%) n=362 |
Control (%) n=358 |
P-valuea | ORb (95% CI) | Pac | AORd (95% CI) |
|---|---|---|---|---|---|---|---|---|
| rs4880 | Additive | TT | 272 (75.1) | 296 (82.7) | 1.00 (Ref) | |||
| CT | 83 (23.0) | 61 (17.0) | 0.037 | 1.481 (1.024–2.142) | 0.045e | 1.484 (1.009–2.182) | ||
| CC | 7 (1.9) | 1 (0.3) | 0.033 | 7.618 (0.931–62.316) | 0.121 | 5.388 (0.642–45.216) | ||
| Dominant | TT | 272 (75.1) | 296 (82.7) | 1.00 (Ref) | ||||
| CT/CC | 90 (24.9) | 62 (17.3) | 0.013 | 1.580 (1.099–2.271) | 0.022e | 1.559 (1.067–2.278) | ||
| Recessive | TT/CT | 355 (98.1) | 357 (99.7) | |||||
| CC | 7 (1.9) | 1 (0.3) | 0.069 | 7.039 (0.862–57.510) | 0.138 | 4.988 (0.595–41.803) | ||
| rs5746136 | Additive | GG | 99 (27.3) | 103 (28.8) | 1.00 (Ref) | |||
| AG | 172 (47.5) | 180 (50.3) | 0.974 | 0.994 (0.703–1.405) | 0.960 | 1.009 (0.703–1.449) | ||
| AA | 91 (25.1) | 75 (20.9) | 0.267 | 1.262 (0.836–1.905) | 0.418 | 1.194 (0.778–1.833) | ||
| Dominant | GG | 99 (27.3) | 103 (28.8) | 1.00 (Ref) | ||||
| AG/AA | 263 (72.7) | 255 (71.2) | 0.671 | 1.073 (0.775–1.148) | 0.715 | 1.065 (0.759–1.496) | ||
| Recessive | GG/AG | 271 (74.9) | 283 (79.1) | 1.00 (Ref) | ||||
| AA | 91 (25.1) | 75 (20.9) | 0.182 | 1.267 (0.895–1.795) | 0.354 | 1.187 (0.826–1.839) |
a
P-values were estimated by unconditional logistic regression.
b
The odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated by unconditional logistic regression.
c
Adjusted P-values (Pas) were estimated by multiple logistic regression after controlling for age, gender, smoking and drinking.
d
The adjusted ORs (AORs) with their 95% CIs were estimated by multiple logistic regression models after controlling for age, gender, smoking and drinking.
e
P<0.05.
SOD, superoxide dismutase; OSSC, oral squamous cell carcinoma, SNP, single nucleotide polymorphism; Ref, reference.