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. Author manuscript; available in PMC: 2013 Dec 12.
Published in final edited form as: J Genet Genomics. 2013 Feb 10;40(3):10.1016/j.jgg.2013.02.001. doi: 10.1016/j.jgg.2013.02.001

Fig. 4. The important role of F-box proteins in skin cancer.

Fig. 4

A: β-TrCP acts as an oncogenic protein that mediates skin carcinogenesis induced by DMBA/TPA and UVB irradiation, in part via targeting the degradation of IκB to activate NF-κB and promoting PDCD4 destruction to enhance protein synthesis. B: SKP2 acts as an oncogenic protein during skin carcinogenesis largely by targeting degradation of p27, ING3 and other yet-to-be identified tumor suppressors. C: FBXW7 acts as a tumor suppressor by targeting the degradation of the c-Jun and c-Myc oncoproteins, but may act as an oncogenic protein by targeting Notch degradation during skin carcinogenesis.