Figure 6. Meta-analysis of post-exposure vaccine efficacy.

The post-exposure activity of various vaccines was tested in fifteen individual experiments including a total number of 726 mice. The data shown is a meta-analysis performed by determining the log₁₀ protection for each individual experiment as follows: log _10protection = median log ₁₀ CFU _controlgroup −log ₁₀ CFU _{vaccinated animal} as described in the material and methods section. Data are displayed as single scatter plot with a black line indicating the median values. Values marked with an asterisk above ESAT-6, H1, and H56 are significantly different from the un-vaccinated control groups as assessed by the non-parametric Kruskall-Wallis multiple comparison test (***, p<0.001, **, p<0.01, *, p<0.05).