Figure 5.

Representative (A) macroscopic and (B) microscopic features of the livers of model B rats. (A) Several white nodules were macroscopically observed following diethylnitrosamine (DEN) treatment (B-3). The gross appearance of the liver treated with DEN and 0.1% silymarin was mostly identical to that of the liver treated with DEN alone (B-4). (B) In the histological analysis, hyperplastic nodules were developed following treatment with DEN (B-3), which was not significantly modified by the silymarin treatment (B-4); original magnification, ×100.