Table 3. Enriched ontologies for genes associated with the cancer phenotypes in whites.

Model/GO code	GO Term	P-value thres hold1	Genes below thres hold2	Genes with ontology3	Fisher's exact p-value	FDR p-value	Genes
Reverse Genetics Model (>2 affected subjects)
GO:0006281	DNA repair	0.0098	27	60	0.00002	0.03	FANCA, FANCI, BRCA1, SLX4, CHD1L, XRCC1
GO:0033554	stress response	0.0098	27	7	0.00003	0.03	FANCA, FANCI, PPP1R15B, BRCA1, SLX4, CHD1L, XRCC1
GO:0006974	DNA damage response	0.0098	27	6	0.00003	0.03	FANCA, FANCI, BRCA1, SLX4, CHD1L, XRCC1
Reverse Genetics Model 2 (>2 affected subjects and Fisher p<0.1)
GO:0006281	DNA repair	0.0098	27	6	0.00002	0.045	FANCA, FANCI, BRCA1, SLX4, CHD1L, XRCC1
GO:0006974	DNA damage response	0.0098	27	6	0.00003	0.045	FANCA, FANCI, BRCA1, SLX4, CHD1L, XRCC1
Additive Model
GO:0000070	mitotic sister chromatid segregation	0.0003	2	2	0.000004	0.004	KIF25, PINX1
GO:0007059	chromosome segregation	0.0003	2	2	0.00004	0.03	KIF25, PINX1
GO:0000279	M phase	0.001	4	3	0.00005	0.03	KIF25, PINX1, FANCA
GO:0022403	cell cycle phase	0.001	4	3	0.00008	0.03	KIF25, PINX1, FANCA
GO:0000087	M phase of mitotic cell cycle	0.0003	2	2	0.00013	0.04	KIF25, PINX1
GO:0000280	nuclear division	0.0003	2	2	0.00013	0.04	KIF25, PINX1
GO:0007067	mitosis	0.0003	2	2	0.00013	0.04	KIF25, PINX1
GO:0048285	organelle fission	0.0003	2	2	0.00016	0.04	KIF25, PINX1
GO:0022402	cell cycle process	0.0010	4	3	0.00017	0.04	KIF25, PINX1, FANCA

All ontologies with an FDR p<0.05 are shown.

(1) The association p-value cut-off that gave the strongest enrichment.

(2) Number of genes with p-values below the p-value cut-off.

(3) Number of genes with the ontology.