Table 4. Association results for enriched DNA repair genes in whites.
| Recessive Model | Additive Model | |||||||||
| Phenotype | Reverse genetics P-value | Reverse genetics P-value | OR | 95%CI | P | OR | 95%CI | P | ||
| BRCA1/rs1799950 | ||||||||||
| ALL | 0.13 | 0.091 | 2.6 | (0.8–8.7) | 0.12 | 1.1 | (0.9–1.4) | 0.31 | ||
| CA | 1 | 1 | 0.8 | (0.3–2.8) | 0.79 | 1.1 | (0.9–1.4) | 0.36 | ||
| ** HEM | 0.009 | 0.008 | 4.9 | (1.5–15.8) | 0.008 | 1.1 | (0.8–1.6) | 0.38 | ||
| MET | 1 | 1 | n/a | n/a | 1.00 | 1.1 | (0.8–1.5) | 0.46 | ||
| SKN | 1 | 1 | 2.3 | (0.3–18.4) | 0.42 | 0.7 | (0.4–1.4) | 0.30 | ||
| CHD1L/rs2275249 | ||||||||||
| ALL | 0.31 | 0.17 | 0.9 | (0.4–2.2) | 0.85 | 1.1 | (0.9–1.3) | 0.50 | ||
| CA | 0.26 | 0.14 | 1.0 | (0.4–2.4) | 0.97 | 1.0 | (0.8–1.2) | 0.95 | ||
| HEM | 0.68 | 1 | 0.6 | (0.1–2.7) | 0.54 | 1.2 | (0.9–1.6) | 0.20 | ||
| **MET | 0.01 | 0.006 | 3.3 | (1.3–8.2) | 0.01 | 1.2 | (0.9–1.6) | 0.17 | ||
| SKNSMB | 1 | 1 | 1.3 | (0.2–10.1) | 0.78 | 1.0 | (0.6–1.6) | 0.98 | ||
| FANCA/rs17233497 | ||||||||||
| ALL | 0.19 | 0.036 | 1.6 | (0.7–3.6) | 0.22 | 1.1 | (0.9–1.3) | 0.19 | ||
| CA | 0.38 | 0.19 | 1.3 | (0.6–3.0) | 0.46 | 1.2 | (1.0–1.4) | 0.11 | ||
| HEM | 0.35 | 0.30 | 1.4 | (0.5–4.1) | 0.57 | 0.9 | (0.7–1.2) | 0.57 | ||
| MET | 0.22 | 0.11 | 1.4 | (0.5–4.2) | 0.54 | 1.0 | (0.8–1.4) | 0.85 | ||
| **SKN | 8.00E-04 | 8.00E-04 | 6.7 | (2.5–18.3) | 1.8E-04 | 1.9 | (1.3–2.7) | 0.001 | ||
| FANCI/POLG/rs3087374 | ||||||||||
| ALL | 0.20 | 0.06 | 1.1 | (0.5–2.4) | 0.90 | 1.0 | (0.9–1.3) | 0.65 | ||
| CA | 0.05 | 0.03 | 1.4 | (0.6–3.2) | 0.42 | 1.1 | (0.9–1.3) | 0.50 | ||
| HEM | 0.36 | 0.21 | 1.4 | (0.5–4.3) | 0.52 | 1.0 | (0.7–1.3) | 0.75 | ||
| **MET | 0.003 | 0.002 | 4.0 | (1.6–9.6) | 0.002 | 1.4 | (1.0–1.8) | 0.02 | ||
| SKNSMB | 1 | 1 | 1.3 | (0.2–10.0) | 0.78 | 1.1 | (0.7–1.8) | 0.70 | ||
| SLX4/rs3810813 | ||||||||||
| ALL | 0.048 | 0.03 | 3.3 | (1.0–10.9) | 0.047 | 1.1 | (0.9–1.4) | 0.42 | ||
| **CA | 0.01 | 0.005 | 4.4 | (1.3–14.4) | 0.01 | 1.1 | (0.9–1.4) | 0.43 | ||
| HEM | 1 | 1 | n/a | n/a | 1.00 | 1.0 | (0.7–1.4) | 0.86 | ||
| MET | 1 | 1 | 1.5 | (0.3–7.1) | 0.60 | 1.1 | (0.8–1.5) | 0.64 | ||
| SKNSMB | 1 | 1 | n/a | n/a | 1.00 | 0.8 | (0.4–1.5) | 0.41 | ||
| XRCC1/rs1799782 | ||||||||||
| ALL | 0.36 | 0.20 | 2.8 | (1.0–8.3) | 0.06 | 1.0 | (0.8–1.3) | 0.75 | ||
| CA | 0.27 | 0.16 | 2.1 | (0.8–5.9) | 0.15 | 1.0 | (0.8–1.3) | 0.82 | ||
| HEM | 0.35 | 0.30 | 1.8 | (0.5–6.5) | 0.38 | 1.0 | (0.7–1.4) | 0.97 | ||
| MET | 0.33 | 1 | 1.9 | (0.5–6.9) | 0.33 | 1.0 | (0.7–1.4) | 0.87 | ||
| **SKN | 0.01 | 0.01 | 7.3 | (2.0–26.5) | 0.002 | 1.2 | (0.7–2.0) | 0.56 | ||
Denotes the mechanistic phenotype driving the DNA repair enrichment.
‘n/a’ indicates there were no affected minor allele homozygotes for the phenotype. The value