Table 5. Association of DNA repair genes in independent data sets.

	Logistic regression comparing HZs1			Additive Model
Phenotype	OR	95% CI	p-value	OR	95% CI	P
eMERGE
FANCA/rs172334972
ALL	1.7	(0.7–4.0)	0.30	1.2	(0.9–1.4)	0.15
CA	1.5	(0.6–3.7)	0.42	1.1	(0.9–1.4)	0.32
HEM	2.0	(0.1–15.2)	0.84	1.2	(0.7–2.3)	0.51
MET	1.1	(0.02–7.1)	1.00	0.8	(0.5–1.5)	0.58
**SKN	4.1	(0.9–13.3)	0.06	1.7	(1.2–2.5)	0.006
FANCI/POLG/rs3087374
ALL	1.4	(0.92–2.0)	0.13	1.0	(0.9–1.1)	0.82
CA	1.4	(0.9–2.1)	0.10	1.0	(0.9–1.1)	0.88
HEM	1.4	(0.6–3.5)	0.41	1.0	(0.8–1.2)	0.84
**MET	2.4	(1.3–4.4)	0.01	1.2	(1.0–1.4)	0.06
SKN	1.2	(0.4–3.8)	0.79	1.1	(0.9–1.4)	0.42
VESPA
BRCA1/rs1799950
ALL	8.1	(1.1–360.6)	0.04	1.0	(0.8–1.2)	0.96
CA	4.5	(0.9–44.4)	0.08	0.9	(0.8–1.1)	0.45
**HEM	0.7	(0.1–5.5)	1.00	1.1	(0.8–1.5)	0.42
MET	1.2	(0.1–6.5)	1.00	1.0	(0.8–1.3)	0.85
SKN	1.3	(0.2–6.1)	0.94	1.3	(0.9–2.0)	0.16
CHD1L/rs2275249
ALL	2.3	(0.9–6.4)	0.09	0.9	(0.8–1.2)	0.62
CA	2.0	(0.8–5.0)	0.17	0.9	(0.7–1.2)	0.49
HEM	0.8	(0.2–2.9)	1.00	0.7	(0.5–1.0)	0.05
**MET	4.1	(1.4–10.8)	0.01	1.2	(0.9–1.6)	0.20
SKN	1.7	(0.6–4.5)	0.37	1.5	(1.0–2.2)	0.06
FANCA/rs17233497
ALL	1.3	(0.6–2.9)	0.59	1.0	(0.8–1.1)	0.74
CA	1.3	(0.6–2.8)	0.67	1.0	(0.8–1.2)	0.94
HEM	1.7	(0.5–4.3)	0.40	1.0	(0.8–1.3)	0.85
MET	0.5	(0.1–1.7)	0.36	0.9	(0.7–1.1)	0.43
**SKN	1.4	(0.2–5.8)	0.92	0.8	(0.6–1.2)	0.35
FANCI/POLG/rs3087374
ALL	0.9	(0.4–2.1)	0.90	0.9	(0.8–1.0)	0.15
CA	0.6	(0.2–1.5)	0.35	0.9	(0.8–1.1)	0.35
HEM	3.5	(1.3–8.7)	0.01	0.9	(0.7–1.2)	0.42
**MET	0.8	(0.2–2.4)	0.89	1.0	(0.8–1.3)	0.83
SKN	n/a	n/a	n/a	0.8	(0.5–1.2)	0.21
SLX4/rs3810813
ALL	2.6	(0.5–16.1)	0.27	1.0	(0.8–1.2)	0.88
**CA	1.3	(0.3–5.9)	0.90	0.9	(0.8–1.1)	0.44
HEM	0.9	(0.02–7.5)	1.00	1.0	(0.7–1.3)	0.99
MET	1.5	(0.2–8.2)	0.86	0.9	(0.7–1.2)	0.59
SKN	n/a	n/a	n/a	0.6	(0.3–1.0)	0.07

(1) This model compared minor allele homozygotes to matched common allele homozygotes.

 = 3,092 subjects). (2) Genotype data for this nsSNP was only available for one eMERGE site (n