Table 3. Linkage of SNPs on KIAA1462/rokimi region of chr10 and LOAD unstratified (all families) and stratified by APOE status.
All families | APOE positive families | APOE negative families | ||||||||||
HETLOD | HETLOD | PDT | MLOD | MLOD | MLOD | MLOD | ||||||
RS# | dom | REC 2pt | SUM | FBAT | dom | rec | PDTsum | FBAT | dom | rec | PDTsum | FBAT |
RS2256283 | 0.33 | 0.10 | 1.000 | 0.997 | 0.24 | 0.05 | 0.739 | 0.879 | 0.10 | 0.05 | 0.587 | 0.850 |
RS3006544 | 0.00 | 0.00 | 0.665 | 0.968 | 0.00 | 0.00 | 0.962 | 0.351 | 0.00 | 0.02 | 0.549 | 0.255 |
RS12764479 | 0.00 | 0.00 | 0.677 | 0.878 | 0.00 | 0.00 | 0.232 | 0.359 | 0.08 | 0.14 | 0.091 | 0.073 |
RS7917431 | 0.24 | 0.25 | 0.483 | 0.528 | 0.02 | 0.03 | 0.652 | 0.453 | 0.41 | 0.45 | 0.587 | 0.891 |
RS1774240 | 0.90 | 0.76 | 0.213 | 0.207 | 0.43 | 0.28 | 0.214 | 0.341 | 0.68 | 0.57 | 0.685 | 0.390 |
RS1774243 | 0.64 | 0.84 | 0.212 | 0.445 | 0.76 | 1.02 | 0.475 | 0.854 | 0.02 | 0.04 | 0.283 | 0.266 |
RS1418278 | 1.73 | 1.66 | 0.515 | 0.360 | 1.11 | 0.89 | 0.291 | 0.160 | 0.69 | 0.79 | 0.775 | 0.870 |
RS1063205 | 0.70 | 0.66 | 0.294 | 0.193 | 0.28 | 0.34 | 0.351 | 0.261 | 0.48 | 0.32 | 0.602 | 0.394 |
RS3739998 | 0.86 | 0.70 | 0.308 | 0.265 | 0.69 | 0.56 | 0.390 | 0.494 | 0.20 | 0.15 | 0.580 | 0.295 |
RS2185724 | 0.11 | 0.10 | 0.572 | 0.416 | 0.04 | 0.08 | 0.513 | 0.464 | 0.07 | 0.02 | 0.904 | 0.733 |
RS9337951 | 1.00 | 0.69 | 0.362 | 0.375 | 0.64 | 0.36 | 0.317 | 0.390 | 0.36 | 0.38 | 0.874 | 0.543 |
RS2487928 | 1.24 | 0.95 | 0.077 | 0.072 | 1.02 | 0.77 | 0.151 | 0.152 | 0.26 | 0.21 | 0.299 | 0.154 |
RS1342150 | 0.48 | 0.29 | 0.077 | 0.046 | 0.17 | 0.06 | 0.236 | 0.317 | 0.37 | 0.30 | 0.186 | 0.032 |
RS2478833 | 0.90 | 0.68 | 0.020 | 0.012 | 0.26 | 0.10 | 0.100 | 0.021 | 0.74 | 1.07 | 0.094 | 0.156 |
RS2505087 | 1.42 | 1.30 | 0.063 | 0.027 | 1.39 | 1.01 | 0.155 | 0.037 | 0.15 | 0.43 | 0.209 | 0.180 |
RS1122730 | 1.96 | 1.07 | 0.235 | 0.235 | 1.67 | 0.76 | 0.581 | 0.430 | 0.37 | 0.32 | 0.203 | 0.257 |
RS2255515 | 0.18 | 0.06 | 0.109 | 0.119 | 0.19 | 0.02 | 0.283 | 0.224 | 0.02 | 0.05 | 0.128 | 0.248 |
RS6481654 | 0.18 | 0.16 | 0.050 | 0.235 | 0.38 | 0.32 | 0.113 | 0.231 | 0.00 | 0.00 | 0.245 | 0.446 |
RS4749527 | 0.37 | 0.30 | 0.286 | 0.395 | 1.31 | 1.13 | 0.298 | 0.292 | 0.00 | 0.00 | 0.752 | 0.783 |
RS2505127 | 0.30 | 0.15 | 0.021 | 0.056 | 0.15 | 0.00 | 0.064 | 0.087 | 0.24 | 0.44 | 0.131 | 0.281 |
RS3847404 | 0.25 | 0.13 | 0.088 | 0.064 | 0.57 | 0.35 | 0.201 | 0.095 | 0.00 | 0.00 | 0.234 | 0.237 |
RS2505126 | 0.94 | 0.60 | 0.005 | 0.013 | 1.07 | 0.68 | 0.017 | 0.015 | 0.03 | 0.01 | 0.129 | 0.173 |
RS12220246 | 0.00 | 2.91 | 0.445 | 0.032 | 0.09 | 2.02 | 0.589 | 0.033 | 0.00 | 0.93 | 0.582 | 0.030 |
RS2488024 | 1.00 | 0.65 | 0.000 | 0.002 | 0.77 | 0.48 | 0.004 | 0.009 | 0.23 | 0.18 | 0.030 | 0.041 |
RS11007904 | 0.72 | 0.56 | 0.096 | 0.167 | 1.27 | 1.16 | 0.098 | 0.087 | 0.00 | 0.00 | 0.630 | 0.750 |
RS1887317 | 1.15 | 1.18 | 0.100 | 0.265 | 0.58 | 0.51 | 0.065 | 0.146 | 0.62 | 0.73 | 0.889 | 0.921 |
RS10826765 | 0.22 | 0.14 | 0.029 | 0.056 | 0.46 | 0.36 | 0.146 | 0.100 | 0.00 | 0.00 | 0.079 | 0.212 |