Figure 4.

Effect of RS postconditioning on HMGB1 expression during I/R (n=5). (A) HMGB1 expression in ischemic areas of left ventricle samples were examined and analyzed by quantitative immunoblotting. The expression of protein was normalized to GAPDH expression. (B) Densitometric analysis of results in (A) following normalization to GAPDH. The results presented are the means ± SD of three independent experiments. ^#P<0.05 vs. SO group; ^▲P<0.05 vs. I/R group. HMGB1, high mobility group box 1 protein; SO, sham-operated control; RS, rosuvastatin; I/R, ischemia-reperfusion.