Table 1. Characteristics of the studies subjects.
| HIFMECH |
CABG | SB-FH |
UDACS |
EARSII |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| controls | MI cases | CHD cases | - CHD | + CHD | - CHD | + CHD |
controls | “MI” cases |
|||
| Number | 559 | 520 | 341 | 222 | 145 | 424 | 142 | 396 | 369 | ||
| % women | 0 | 0 | 20.8 | 56.8 | 33.8* | 43.2 (183) | 31.7 (45)* | 0 | 0 |
||
| Age (years) | 51.1 (5.5) | 51.9 (5.4) | 64.9 (9.2) | 44.3 (13.4) | 56.1 (10.3)* | 65.8 (11.3) | 69.3 (9.7)* | 22.7 (0.1) | 22.7 (0.1) |
||
| BMI (kg/m2) | 26.1 (3.2) | 27.1 (3.3)* | 28.2 (4.5) | 23.8 (4.0) | 25.1 (3.4)* | 29.3 (5.6) | 29.6 (5.4) | 23.3 (0.1) | 23.4 (0.1) | ||
| CRP (mg/l) | 1.23 (1.40) | 2.22 (2.55)* | 2.29 (2.77) | 1.16 (1.34) | 1.42 (1.59) | 1.70 (1.45) | 1.82 (1.60) | 0.43 (0.50) | 0.48 (0.57) | ||
| Cholesterol (mmol/l) | 5.52 (0.97) | 5.40 (1.18) | 4.71 (1.03) | 6.91 (1.30) | 6.35 (1.31)* | 5.19 (1.07) | 4.73 (1.12)* | 4.30 (0.04) | 4.53 (0.04)* | ||
| Glucose (mmol/l) | 6.19 (2.05) | 4.82 (0.59) | 5.07 (0.59)* | 9.96 (4.31) | 9.65 (4.24) | 5.17 (0.02) | 5.16 (0.02) | ||||
| Insulin (mU/l) | 37.8 (24.3) | 49.3 (34.5)* | - | - | 10.6 (0.2) | 10.1 (0.2) | |||||
| Unadjusted LTL (kb) | 8.04 (4.51) | 7.90 (4.05) | 6.85 (4.23) | 9.82 (4.88) | 9.04 (4.74)* | 6.98 (3.50) | 6.80 (3.50) | 9.09 (6.61) | 8.58 (6.71) | ||
For age and cholesterol results are mean (standard deviation). For BMI, CRP, Glucose, insulin and LTL results are geometric mean (approximate standard deviation). EARS “MI” cases are actually sons of MI patients.
BMI, body mass index; LTL, leukocyte telomere length.
P values are from two-sample t-test; LTL were adjusted for age, gender, center as appropriate using multiple regression. For the UDACS study, analysis was limited to the Caucasian population.
* indicates that the difference between cases and controls was significant with p<0.05.