Table 2. Cox proportional hazard regression model of Breast Cancer-Specific Survival.
| Univariate | Multivariate | |||
| Variablea | HR (95%CI) | P | HR (95%CI) | P |
| Reconstruction type | ||||
| Mastectomy only | 1.00 | - | 1.00 | - |
| Pooled reconstruction | 0.74 (0.68–0.80) | <0.001 | 0.87 (0.80–0.95) | 0.001 |
| Autologous only | 0.83 (0.74–0.93) | 0.001 | 0.90 (0.80–1.01) | 0.065 |
| Implant only | 0.61 (0.51–0.72) | <0.001 | 0.80 (0.68–0.96) | 0.014 |
| Age, y | ||||
| <45 | 1.39 (1.30–1.49) | <0.001 | 1.16 (1.08–1.25) | <0.001 |
| 45–64 | 1.00 | - | 1.00 | - |
| >64 | 1.16 (1.08–1.24) | <0.001 | 1.41 (1.32–1.52) | <0.001 |
| Race | ||||
| White | 1.00 | - | 1.00 | - |
| Black | 1.95 (1.80–2.12) | <0.001 | 1.39 (1.28–1.51) | <0.001 |
| Otherb | 0.85 (0.77–0.95) | 0.003 | 0.88 (0.79–0.97) | 0.014 |
| Marital status | ||||
| Married | 1.00 | - | 1.00 | - |
| Not marriedc | 1.31 (1.24–1.39) | <0.001 | 1.17 (1.10–1.24) | <0.001 |
| Year of diagnosis | ||||
| 1998–2000 | 1.00 | - | 1.00 | - |
| 2001–2002 | 0.95 (0.90–1.01) | 0.106 | 0.92 (0.87–0.97) | 0.003 |
| County type | ||||
| Metropolitan | 1.00 | - | 1.00 | - |
| Nonmetropolitan | 0.98 (0.90–1.06) | 0.630 | 1.07 (0.98–1.16) | 0.132 |
| County educationd | ||||
| High | 1.00 | - | 1.00 | - |
| Low | 1.18 (1.12–1.25) | <0.001 | 1.02 (0.96–1.08) | 0.579 |
| Laterality | ||||
| Right | 1.00 | - | 1.00 | - |
| Left | 1.02 (0.97–1.08) | 0.454 | 1.02 (0.96–1.08) | 0.507 |
| Tumor size | ||||
| <2 cm | 1.00 | - | 1.00 | - |
| 2–5 cm | 3.25 (3.03–3.49) | <0.001 | 1.93 (1.79–2.08) | <0.001 |
| >5 cm | 6.49 (5.94–7.11) | <0.001 | 2.72 (2.47–3.00) | <0.001 |
| Gradee | ||||
| I | 1.00 | - | 1.00 | - |
| II | 3.40 (2.86–4.04) | <0.001 | 2.28 (1.91–2.71) | <0.001 |
| III | 7.42 (6.27–8.77) | <0.001 | 3.25 (2.73–3.86) | <0.001 |
| Node status | ||||
| Negative | 1.00 | - | 1.00 | - |
| 1–3 positive nodes | 2.45 (2.28–2.64) | <0.001 | 2.08 (1.93–2.25) | <0.001 |
| >3 positive nodes | 5.86 (5.46–6.29) | <0.001 | 4.10 (3.78–4.44) | <0.001 |
| ERf | ||||
| Positive | 1.00 | - | 1.00 | - |
| Negative | 2.29 (2.16–2.42) | <0.001 | 1.41 (1.30–1.53) | <0.001 |
| PRf | ||||
| Positive | 1.000 | - | 1.00 | - |
| Negative | 2.12 (2.00–2.24) | <0.001 | 1.38 (1.28–1.49) | <0.001 |
| Radiotherapy | ||||
| Yes | 1.00 | - | 1.00 | - |
| No | 0.45 (0.43–0.48) | <0.001 | 1.06 (0.99–1.13) | 0.073 |
Table 2.a Adjusted by Cox proportional hazards models including all factors, as categorized in
b Including American Indian/AK Native, Asian/Pacific Islander.
c Including divorced, widowed, single (never married),separated.
% of individuals having over a 12th grade education level; Low indicates a county with less than 78.0% (including 78.0%) of individuals having over a 12th grade education level. (78.0% is the median of all county education data studied).d High indicates a county with greater than 78.0
e Grade are coded as followings: Well differentiated; Grade I; Moderately differentiated; Grade II; Poorly differentiated; Grade III; Unknown.
f ER: Estrogen Receptor; PR: Progesterone Receptor.