Figure 1. The number of thymocyte subsets was significantly increased in allo-BMT recipients after rIL-7/HGFβ treatment.

Lethally irradiated mice (BALB/c, 4-10 week old) were injected i.v. with 2 X10⁶ TCD-BM from B6 mice. Groups of mice were then injected i.p. with the equimolar amounts of rIL-7/HGFβ (15 μg), rIL-7 (5 μg) and/or rHGFβ (10 μg), or PBS at 2-day intervals from days 1 to 26 after BMT. The number of (A) total thymocytes, donor-origin (B) CD4 and CD8 DN, (C) CD4 and CD8 DP, (D) CD4 SP, and (E) CD8 SP thymocytes was analyzed on day 30 after BMT. Means + S.D. are presented. The data are representative of 2 independent experiments with 4-6 mice per group. * P<0.05 compared with PBS-treated mice. ** P<0.05 compared with rIL-7 and/or rHGFβ-treated mice.