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. 2013 Dec 12;8(12):e82998. doi: 10.1371/journal.pone.0082998

Figure 3. The number of ETPs and TECs was significantly increased in allo-BMT recipients after rIL-7/HGFβ treatment.

Figure 3

Lethally irradiated BALB/c mice were injected with TCD-BM from B6 mice and treated with cytokines as in Figure 1. On day 30 after BMT, ETPs and TECs were analyzed. (A) Representative flow cytometric profiles showing the percentage of donor-origin lineage- c-kit+ IL-7Rα- CD44+CD25- ETPs in total thymocytes. (B) Number of donor-origin ETPs in the cytokine-treated BMT mice. (C) Representative flow cytometric profiles showing the percentage of CD45-EpCAM+MHC II+Ly51+ cTECs and CD45-EpCAM+MHC II+Ly51- mTECs in total TECs of the rIL-7/HGFβ-treated BMT mice. (D) Number of total TECs, cTEC and mTECs in the cytokine-treated BMT mice. The data are representative of 2 independent experiments with 4-6 mice per group. * P<0.05 compared with PBS-treated mice. ** P<0.05 compared with rIL-7 and/or rHGFβ-treated mice.