Table III.

Common dysregulated pathways identified by gene set enrichment analysis (GSEA).

Pathway names	Classification	Genes
Upregulated pathways
Cytokine-cytokine receptor interaction	Signaling molecules and interaction	50
Chemokine signaling pathway	Immune system	42
Antigen processing and presentation	Immune system	30
Jak-STAT signaling pathway	Signal transduction	30
Natural killer cell mediated cytotoxicity	Immune system	33
Type I diabetes mellitus	Metabolic diseases	25
Asthma	Immune system diseases	11
Autoimmune thyroid disease	Immune system diseases	18
Systemic lupus erythematosus	Immune system diseases	44
Allograft rejection	Immune system diseases	18
Graft-versus-host disease	Immune system diseases	15
Primary immunodeficiency	Immune system diseases	11
Downregulated pathways
Citrate cycle (TCA cycle)	Carbohydrate metabolism	20
Fatty acid metabolism	Lipid metabolism	34
Oxidative phosphorylation	Energy metabolism	28
Alanine, aspartate and glutamate metabolism	Amino acid metabolism	17
Glycine, serine and threonine metabolism	Amino acid metabolism	22
Valine, leucine and isoleucine degradation	Amino acid metabolism	31
Arginine and proline metabolism	Amino acid metabolism	29
Tyrosine metabolism	Amino acid metabolism	14
Tryptophan metabolism	Amino acid metabolism	20
β-alanine metabolism	Metabolism of other amino acids	15
Selenoamino acid metabolism	Metabolism of other amino acids	15
Pyruvate metabolism	Carbohydrate metabolism	20
Propanoate metabolism	Carbohydrate metabolism	21
Butanoate metabolism	Carbohydrate metabolism	23
Retinol metabolism	Metabolism of cofactors and vitamins	17
Cardiac muscle contraction	Circulatory system	10
Tight junction	Cell communication	26

Genes: Number of common genes included in the pathway.