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. Author manuscript; available in PMC: 2014 Nov 6.
Published in final edited form as: J Am Chem Soc. 2013 Oct 22;135(44):10.1021/ja408595e. doi: 10.1021/ja408595e

Figure 8.

Figure 8

(A) A sample trajectory of the end-to-end distance as a function of time for the riboswitch in the presence of SAM during the stretch-quench (fs − fq) cycles with tq = 0.3 ms, fs = 20 pN, and fq = 8 pN. The green line represents the force changes during the fs − fq cycles. (B) Same as (A) except tq = 1 ms. (C) Distributions, P(τU) of unfolding times for the RNA riboswitch with SAM bound obtained during the fs − fq cycles (see (A) and (B)) with relaxation time period, tq = 0.1 ms, 0.3 ms, 0.5 ms, 0.7 ms, and 1 ms. During tq the force f = fq = 8 pN. For tq in red P(τU)s are invariant, which means that these tq values are large enough for the RNA to fold.