Figure 5.

HMGN2 protein suppresses the growth of Tca8113 cell xenografts in vivo. (A) Tumor volume following HMGN2 treatment. (B) Final tumor weight at necropsy, 12 days after seeding. Data are presented as mean ± SEM. ^*P<0.05, vs. negative group. (C) Tca8113 xenografts from each treatment group. HMGN2 protein expression induced necrosis in Tca8113-xenografted tumor tissues. (D) Paraffin-embedded sections of representative Tca8113 xenografts analyzed by hematoxylin and eosin staining. Arrows indicate necrotic tissue. HMGN2, high mobility group nucleosomal binding domain 2.