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AEG-1 inhibition reduces activation of Stat3 signaling. (A) Stat3 expression levels were suppressed by AEG-1 silencing in HepG2 cells, as detected by western blotting. GAPDH was used as a loading control. (B) Stat3 target genes were downregulated in HepG2 cells with AEG-1 silencing, as detected by qPCR (*P<0.05). AEG-1, astrocyte-elevated gene-1; GAPDH, GAPDH, glyceraldehyde 3-phosphate dehydrogenase; qPCR, quantitative polymerase chain reaction; Cryab, crystalin, αB.
