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Sequence alignments for TM domains of human α7 and β2 nAChRs. Sequences of the constructs used for NMR samples, α7′ and β2′, are aligned with their respective native sequences. Note that only a few terminal and loop residues were changed to increase the stability of NMR samples. The labeled sequence numbers are for the α7 nAChR. The pore lining residues are labeled using the conventional prime numbering. Residues in the box were mutated in the study.
