Fig. 2.

The family usage of VH3 and VH4 peptides in MScl in comparison to controls. The family usage of the IgH repertoire expressed in the CSF of MScl patients and controls. Horizontal lines represent median values. Peptide counts were normalized at the individual patient level to the total number of peptides in given family. Frequencies (percentage) of peptides are plotted along the y-axis. The usage of peptides assigned to each family was compared between the two groups. A slight overrepresentation of the VH4 family (Mann–Whitney test, p = 0.03) was observed in the MScl patient group (n = 29) relative to the control group (n = 30).